In this tutorial we will use the Safety Intelligence System to identify those compounds that cause fibrosis in the liver. It includes:

• using quick search to identify all the terms or synonyms containing the term fibrosis
• selecting a sub-set of terms of interest
• using this sub-set of terms as a starting point for a second quick search to identify those compounds with a relationship to the fibrosis terms of interest
• exporting the data (including SMILES strings) to Microsoft Excel for further analysis

The tutorial lasts for just over 2 minutes.

SIP Quick Search Tutorial - Compounds that cause fibrosis

In this tutorial, we will use some of the advanced search capabilities of the Safety Intelligence System to investigate how carboxylic acids may be involved in hepatotoxicity. Do they show an unusual profile compared to compounds that do not contain a carboxylic acid sub-structure? Is there a particular type of hepatotoxic affect, e.g. oxidation or oxidative stress. The tutorial will take around 5 minutes to complete. You can also download below the poster presented at the Society Of Toxicology, Seattle, 2008.  In performing this analysis we will use:

• Searching by chemical sub-structure
• User defined term list
• Advanced searches between types of term, for example, compounds to biomedical observations
• Exporting data for further analysis

SIP Advanced Search Tutorial - Investigating the role of Carboxylic Acids in Hepatotoxicity

Safety Intelligence Program - Carboxylic Acids Study

This tutorial uses the Safety Intelligence System to understanding the effects of bromobenzene compounds in the human liver. The tutorial includes:

• using the chemistry searching functionality to identify those compounds that contain the bromobenzene sub-structure
• saving these compounds to a user specific term list
• conducting an advanced search using the term list created to any liver effect and using the species filter to limit the results to humans only
• using the built in hyperlinking functionality to view the original source of the intelligence
• exporting the data (including SMILES strings) for further analysis in Microsoft Excel

The tutorial will take about 3 minutes to run.

SIP Chemistry Search - The effects of bromobenzene compounds in the human liver