The liver is an important indicator of drug toxicity. It deals with toxins and many medicinal products that pass through the body, and as such, has a high chance of being exposed to drug toxicity. More than 900 drugs, toxins and herbs are known to cause liver injury1. Hepatic injury is a common reason for drug withdrawal, but can be difficult to detect as many drugs only cause it infrequently2.
The Safety Intelligence Program (SIP) is a knowledgebase of comprehensive intelligence, built from a wide set of public domain sources, around compounds causing adverse effects in tissues, including effects on biomarkers of tissue injury and also molecular mechanisms.
The data in SIP can be accessed via both drug class and chemical structure searches, meaning that drugs with similar structures and other properties can be compared to a drug in development. This means that potential hepatotoxicity could be detected earlier in the drug development process, which could potentially lead to large savings.