Metawise is a unique and powerful ontology that can identify, translate and connect medically relevant relationships expressed in scientific content. Metawise uses intelligent metadata that is aligned to both reference (e.g. accession number, HGNC term, MedDRA term) or referent (e.g. Disease, Drug, Target, Pathway, Tissue) categories to harmonize differing terminology and semantics. It can also be used to translate terms used by different communities or software applications (e.g. switching from a two dimensional chemical structure to a drug name or a SMILES string. This extends the utility and value of the data whilst preserving the integrity of the original data.