Tag Archives: BioWisdom

Instem Scientific’s Safety Intelligence Programme (SIP) now contains in-depth coverage of adverse effects on skin

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SIP is a knowledgebase of toxicological and pathological adverse effects of drugs and other compounds.  It contains deep coverage of biomedical observations (BMOs) occurring in many different tissues (e.g. liver, heart), and we can now add skin (including appendages such as hair and nail) to that list.

The skin is an important organ, being the largest in the body, and is affected by a wide variety of different drugs, including those administered topically and subcutaneously as well as via other routes.

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Safety Intelligence Program Provides Insight into Drug-Induced Cardiac Effects

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The Safety Intelligence Program (SIP) is a comprehensive knowledgebase of intelligence based around adverse effects of drugs and other compounds.  It contains in-depth knowledge of drug effects in various tissues, including the cardiovascular system.

Drug-induced cardiotoxicity

Cardiotoxicity is a major adverse effect of drugs and has led to a number of withdrawals, for example terfenadine (withdrawn due to arrhythmia) and cisapride (sudden cardiac death and arrhythmia), and more recently for sibutramine (myocardial infarction).  It also caused restrictions to be placed on some drugs (such as thioridazine), delays in regulatory approval, and late-stage compound failures.  According to Drug Discovery World¹, drugs causing cardiotoxicity (such as heart damage and arrhythmia) have caused 28% of drug withdrawals in the United States over the past 30 years.
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Intelligent Metadata

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Intelligence MetadataBioWisdom specializes in the application of ‘Intelligent Metadata’ to enhance the value of your data for your business. Key Concept Metadata (KCM) is used to annotate, translate and connect critical concepts expressed in structured and unstructured records. KCM can be used for Knowledge Discovery – text mining and enterprise search. KCM can be used for organising, categorising, filtering and channeling documents; for aligning and comparing key concepts such as assets and liabilities.

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